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Slack / Private Message Drop, p.367 [SLACK_000581] · slack_pm:msg:03825

Date: 2021-01-07 16:16
Type: chat message · slack
mentioned: Andrew Rambaut
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry
Topics: Vaccines

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@Andrew Rambaut Yeah - truly. At this point it's literally a guess as to what to change the spike to in v2.0 vaccines. Does E484K induce a good immune response against E484 viruses or is Erik a total escape from the humanrepertoire[s]? I doubt it, but who knows. Need to get some plasma from people that have been infected with the UKand ZA variants to see if they actually recognize the putative epitopes are not.

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2021-01-07 15:51 Edward C. Holmes open

@Andrew Rambaut Evolution is a pain in the arse.
2021-01-07 16:16 Robert F. Garry

@Andrew Rambaut Yeah - truly. At this point it's literally a guess as to what to change the spike to in v2.0 vaccines. Does E484K induce a good immune response against E484 viruses or is Erik a total escape from the humanrepertoire[s]? I doubt it, but who knows. Need to get some plasma from people that have been infected with the UKand ZA variants to see if they actually recognize the putative epitopes are not.
2021-01-07 16:29 Andrew Rambaut open

@Andrew Rambaut Plenty of that plasma around at the moment in the UK
2021-01-07 17:05 Kristian G. Andersen open

@Andrew Rambaut "Does E484K induce a good immune response against E484 viruses or is Erik a total escape from the human repertoire[s]? I doubt it, but who knows". I was wondering about this very same question yesterday... I assume an updated spike protein should likely do it, but as you say, who knows (if it's not, I'm going toshoot myself).

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