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Slack / Private Message Drop, pp.366-367 [SLACK_000580] · slack_pm:msg:03820

Date: 2021-01-07 12:59
Type: chat message · slack
mentioned: Andrew Rambaut
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry
Topics: Vaccines

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@Andrew Rambaut I know, but current consensus [Bloom, Rasmussen, even Fauci but he's always cagey] is that the existing vaccines will induce "polyclonal" immunity that will protect against viruses with just a few mutations. Iwould say that was true, BUT Nelly and Erik sure look like immune escape variants not to mention K417N and the NTD mutants. IMO not too soon to start tuning up v2 of those vaccines. I would not assume this has started.

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Statement	Grade	Attribution	Stance
@Andrew Rambaut I know, but current consensus [Bloom, Rasmussen, even Fauci but he's always cagey] is that the existing vaccines will induce "polyclonal" immunity that will protect against viruses with just a few mutations.	quoted / not their view	quoted_external sentence carries quotation marks	asserts

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quoted / not their view

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2021-01-07 12:00 Kristian G. Andersen open

Wait - they haven't already found the answers to all their questions? I thought this mission would be easy peasy.
2021-01-07 12:02 Andrew Rambaut open

@Robert Garry Amazing how much power resides in one person and how the power is mainly through control of a diary.
2021-01-07 12:41 Robert F. Garry open

@Andrew Rambaut Someone needs to take some combo of Doug, Nelly and Erik and probably a few other siblings and make vaccines and monoclonals that work against them.
2021-01-07 12:48 Kristian G. Andersen open

@Andrew Rambaut I assume - bloody hope! - Pfizer and Moderna already have these cloned and in animals...
2021-01-07 12:59 Robert F. Garry

@Andrew Rambaut I know, but current consensus [Bloom, Rasmussen, even Fauci but he's always cagey] is that the existing vaccines will induce "polyclonal" immunity that will protect against viruses with just a few mutations. Iwould say that was true, BUT Nelly and Erik sure look like immune escape variants not to mention K417N and the NTD mutants. IMO not too soon to start tuning up v2 of those vaccines. I would not assume this has started.
2021-01-07 13:02 Kristian G. Andersen open

@Andrew Rambaut I hope they're correct that the vaccines will work just fine - I'm certainly less confident making such statements and unwilling to speculate until I have seen some of the UK neut data.

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