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Slack / Private Message Drop, pp.352-353 [SLACK_000566] · slack_pm:msg:03693

Date: 2021-01-02 12:37
Type: chat message · slack
mentioned: Andrew Rambaut
recipient: Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker: Kristian G. Andersen
Topics: Therapeutics and treatments

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Spoke to the Danes this morning and saw some additional data not yet public - essentially the same picture as theUK, so this looks to be real-real. @Andrew Rambaut - they mentioned that the UK had tested the virus against convalescent plasma and there was_no_ effect on neutralization? I'm not quite sure that has actually been done yet - do you know?

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Statement	Grade	Attribution	Stance
Spoke to the Danes this morning and saw some additional data not yet public - essentially the same picture as theUK, so this looks to be real-real. @Andrew Rambaut - they mentioned that the UK had tested the virus against convalescent plasma and there was_no_ effect on neutralization?	needs context	speaker_own	questions

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needs context

speaker_own

questions

In context

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2021-01-02 12:25 Andrew Rambaut open

He is just trying to squirm out of the hole he dug himself.
2021-01-02 12:26 Andrew Rambaut open

Both lineages clearly do stand out. Sure there are a handful of individual sequences that stick out as much but Isuspect most of these are from those immunocompromised patient papers like the one in NEJM
2021-01-02 12:35 Kristian G. Andersen open

Sometimes it's so much easier to just say "shit, I was wrong", instead of proving that you're ignorant to basic phylogenetics and epi. It's a little shocking to be honest - I mean, the guy's been writing papers on this stuff...
2021-01-02 12:37 Kristian G. Andersen

Spoke to the Danes this morning and saw some additional data not yet public - essentially the same picture as theUK, so this looks to be real-real. @Andrew Rambaut - they mentioned that the UK had tested the virus against convalescent plasma and there was_no_ effect on neutralization? I'm not quite sure that has actually been done yet - do you know?
2021-01-02 12:41 Andrew Rambaut open

I have not heard the neutralization information yet - but I have been off the daily calls. I guess this was done in PHEColindale so they may have talked to Denmark directly.
2021-01-02 12:41 Andrew Rambaut open

Just been chatting with Mads and have offered to help them set up a simple BEAST run to estimate the growth rate for the initial stages. Might be a bit too little data just now.
2021-01-02 12:42 Andrew Rambaut open

They clearly have one main lineage that is growing (and a handful of other introductions that are probably going nowhere).
2021-01-02 12:57 Kristian G. Andersen open

Thanks Andrew - I suspect they might have talked to them directly, or they're just going with what Twitter is saying since people are confused... It'd be great if the DK folks could get a little help setting up BEAST. I enquired this morning about their ability to use the genomics directly to estimate growth rates and they seemed very confused - I honestly don't think there's asingle person in DK who knows how to run it. Amazing dataset though! Separately, I'm talking to Mads' boss, so I'll mention the need to use the genomics data more directly as well.

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