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Slack / Private Message Drop, p.346 [SLACK_000560] · slack_pm:msg:03639

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@Eddie Holmes Interesting stuff going on in ORF1 too

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A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2020-12-28 16:00 Edward C. Holmes open

If it is moving around zoos in an airborne manner then the infections in felids are even more striking as you would expect supposedly high risk animals like great apes also to be infected. Yet, it is consistently not apes and consistently is tigers.
2020-12-28 16:41 Kristian G. Andersen open

@Eddie Holmes That _*is*_ close - interesting....
2020-12-28 16:43 Kristian G. Andersen open

@Robert Garry - not sure if there were changes in the passaged viruses - something to ask Mark when he's back (1/4 - same for the rest of the lab).
2020-12-28 17:28 Edward C. Holmes open

@Eddie Holmes And here's a simplot. There's clearly a region from ~8-18 Kb where it is about as close to SARS-CoV-2 as RaTG13... [shared file(s): SimPlot.bmp]
2020-12-28 17:35 Kristian G. Andersen

@Eddie Holmes Interesting stuff going on in ORF1 too
2020-12-28 17:35 Edward C. Holmes open

@Eddie Holmes Indeed.
2020-12-28 17:36 Kristian G. Andersen open

@Eddie Holmes I hate coronaviruses - so many trees across different parts of the genome - clearly they're just shuffling shit around like they were bacteria. Pretty concerning.
2020-12-28 17:47 Edward C. Holmes open

@Eddie Holmes Yes, and trying to work out the exact history of recombination events is bloody difficult.