Chat message

Slack / Private Message Drop, p.346 [SLACK_000560] · slack_pm:msg:03638

Date: 2020-12-28 17:28
Type: chat message · slack
recipient: Kristian G. Andersen, Robert F. Garry, Andrew Rambaut
speaker: Edward C. Holmes

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@Eddie Holmes And here's a simplot. There's clearly a region from ~8-18 Kb where it is about as close to SARS-CoV-2 as RaTG13... [shared file(s): SimPlot.bmp]

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2020-12-28 15:14 Robert F. Garry open

The cats are very interesting as previously discussed here. Surely seems like they are getting infected pretty easily.In the zoos the cats are probably getting infected by the airborne route. People coughing and breathing into open cages? I suppose that the zookeepers could infecting them somehow, but there are not too many instances ofpeople and these big cats together in very close quarters except under very controlled conditions [like a vet doing anexam]. As for origins, it does put a heavy spotlight back on the Feliforms.
2020-12-28 16:00 Edward C. Holmes open

If it is moving around zoos in an airborne manner then the infections in felids are even more striking as you would expect supposedly high risk animals like great apes also to be infected. Yet, it is consistently not apes and consistently is tigers.
2020-12-28 16:41 Kristian G. Andersen open

@Eddie Holmes That _*is*_ close - interesting....
2020-12-28 16:43 Kristian G. Andersen open

@Robert Garry - not sure if there were changes in the passaged viruses - something to ask Mark when he's back (1/4 - same for the rest of the lab).
2020-12-28 17:28 Edward C. Holmes

@Eddie Holmes And here's a simplot. There's clearly a region from ~8-18 Kb where it is about as close to SARS-CoV-2 as RaTG13... [shared file(s): SimPlot.bmp]
2020-12-28 17:35 Kristian G. Andersen open

@Eddie Holmes Interesting stuff going on in ORF1 too
2020-12-28 17:35 Edward C. Holmes open

@Eddie Holmes Indeed.
2020-12-28 17:36 Kristian G. Andersen open

@Eddie Holmes I hate coronaviruses - so many trees across different parts of the genome - clearly they're just shuffling shit around like they were bacteria. Pretty concerning.
2020-12-28 17:47 Edward C. Holmes open

@Eddie Holmes Yes, and trying to work out the exact history of recombination events is bloody difficult.

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