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Slack / Private Message Drop, p.342 [SLACK_000556] · slack_pm:msg:03602

Date: 2020-12-23 07:36
Type: chat message · slack
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry

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TM domain 4 has the seemingly odd arginine. This is a sign of dimerization. That and the fact that the loop connectsto this TM domain raises the suspicion these are part of the business/regulatory bits of the protein.

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2020-12-23 07:24 Kristian G. Andersen open

A lot of good stuff here Bob - thanks! And for Nelly, maybe we're too focused on spike alone...
2020-12-23 07:27 Robert F. Garry open

Right on cue - nonSpike protein nsp6 @Andrew Rambaut as predicted - the deletion is in a large external loop - very likely to impact nsp6 function or regulation!
2020-12-23 07:28 Robert F. Garry open

shared file(s): image.png
2020-12-23 07:36 Robert F. Garry

TM domain 4 has the seemingly odd arginine. This is a sign of dimerization. That and the fact that the loop connectsto this TM domain raises the suspicion these are part of the business/regulatory bits of the protein.
2020-12-23 07:48 Robert F. Garry open

AS for S477N - it would not surprise me to find that it's a contact residue with ACE2 - the ACE2 structures lack the nterminus (blue arrow) so plenty of opportunity for interactions.
2020-12-23 07:54 Robert F. Garry open

S477 [shared file(s): image.png]

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