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Slack / Private Message Drop, p.342 [SLACK_000556] · slack_pm:msg:03599

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A lot of good stuff here Bob - thanks! And for Nelly, maybe we're too focused on spike alone...

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2020-12-23 07:24 Kristian G. Andersen

A lot of good stuff here Bob - thanks! And for Nelly, maybe we're too focused on spike alone...
2020-12-23 07:27 Robert F. Garry open

Right on cue - nonSpike protein nsp6 @Andrew Rambaut as predicted - the deletion is in a large external loop - very likely to impact nsp6 function or regulation!
2020-12-23 07:28 Robert F. Garry open

shared file(s): image.png
2020-12-23 07:36 Robert F. Garry open

TM domain 4 has the seemingly odd arginine. This is a sign of dimerization. That and the fact that the loop connectsto this TM domain raises the suspicion these are part of the business/regulatory bits of the protein.
2020-12-23 07:48 Robert F. Garry open

AS for S477N - it would not surprise me to find that it's a contact residue with ACE2 - the ACE2 structures lack the nterminus (blue arrow) so plenty of opportunity for interactions.