Chat message

Slack / Private Message Drop, p.338 [SLACK_000552] · slack_pm:msg:03557

Recipients on this medium are inferred from channel membership, not per-message addressing.

Just noting that Q493K made the list of mutations discussed in channel above in the NEJM immunosuppressed patient who got the Regeneron MAbs.

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2020-12-22 05:54 Robert F. Garry open

The development of monoclonal antibody resistant mutants (MARMs) is an important clue that immune escape might be driving the emergence of the various Nellys and the elephant. K417, E484 and Q493 make the list of MARMs to various Regeneron MAbs (see Table 2). The presence of Q493K on the list of MARMs suggests that in the Baric and Sun mouse passage experiments immune section could have played a role in the emergence of the mouse pathogenic variant. https://science.sciencemag.org/content/369/6506/1014
2020-12-22 06:10 Robert F. Garry

Just noting that Q493K made the list of mutations discussed in channel above in the NEJM immunosuppressed patient who got the Regeneron MAbs.