Private channel session 711

2 messages over 16m, 2020-12-22 – 2020-12-22.

A “conversation” here is an activity session — a run of messages with under 60 minutes of silence inside it. The channel had no native conversation boundaries.

1. 2020-12-22 05:54 Robert F. Garry open PDF p.338
   The development of monoclonal antibody resistant mutants (MARMs) is an important clue that immune escape might be driving the emergence of the various Nellys and the elephant. K417, E484 and Q493 make the list of MARMs to various Regeneron MAbs (see Table 2). The presence of Q493K on the list of MARMs suggests that in the Baric and Sun mouse passage experiments immune section could have played a role in the emergence of the mouse pathogenic variant. https://science.sciencemag.org/content/369/6506/1014
2. 2020-12-22 06:10 Robert F. Garry open PDF p.338
   Just noting that Q493K made the list of mutations discussed in channel above in the NEJM immunosuppressed patient who got the Regeneron MAbs.