A single line often inverts meaning once you see what it
answers, so neighbouring messages are always shown.
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Just found a genome from mid July that has N501Y and the ORF8 stop Possibly part of the precursor lineage.
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From Sun: "In our previous study, we generated a mouse-adapted strain of SARS-CoV-2 (MASCp6) by 6 serial passages of a SARS-CoV-2 in the lung of *aged* BALB/c mice, which caused moderate lung damage and no fatality in mice. Herein, we further serially passaged for additional 30 times to generate a more virulent SARS-CoV-2, and the resulting virus at passage 36 ( named as MASCp36) was used for stock preparation and titration." And a little deeper dive into the supplement reveals that N501Y came up early - by 6 passages [and it wasn't pathogenic] the other 2 muts took more passages [and tjhose mutations - probably Q493K actually made the virus pathogenic for mice. . Aged mice are definitely immunosuppressed. So, evidence for the immunocompromised theory.
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https://www.bbc.com/news/world-asia-china-55364445
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We should offer to go do it.
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2020-12-21 16:13
Kristian G. Andersen
YES - we can collect our fat checks at the same time!
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One question I'd ask - "Since you faked RaTG13, why haven't you faked a closely related ancestral strain from a random intermediate host?"
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Has anyone tried translating it out of frame? Perhaps it says "MADEINCHINA"?
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"FUNGFLUPATENTPENDING"
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```Sars-Cov-2, the authors concluded, was likely to have gained its unique efficiency through a long, undetected period of circulation in humans or animals of a natural and milder precursor virus that eventually evolved into thepotent, deadly form first detected in Wuhan in 2019.```Eh?