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Slack / Private Message Drop, p.329 [SLACK_000543] · slack_pm:msg:03455

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I bet that is a chronic patient

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A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2020-12-20 13:16 Andrew Rambaut open

There are actually 2 501Y lineages in the UK - the other one in South Wales (now up to about 500 genomes but associated with a hospital outbreak as well). Again only N501Y in common. As you say - there was a cluster in Australia - 37 genomes from beginning of June to beginning of July.
2020-12-20 13:18 Kristian G. Andersen open

I missed that - I thought same lineage, but two separate emergence events (from a common source, I assumed). ButI see the differences on Emma's Nextstrain build - very interesting.
2020-12-20 13:19 Andrew Rambaut open

There are 5 from Massachusetts with a shit load of mutations
2020-12-20 13:19 Andrew Rambaut open

Spike A1020S, Spike C15del, Spike D614G, Spike G142del, Spike I870V, Spike L18del, Spike L141del, Spike N17del, Spike N440D, Spike N501Y, Spike Q14del, Spike Q183H, Spike Q493K, Spike S12del, Spike S13del, Spike S494P, Spike T478K, Spike V16del, Spike V143del, Spike Y144F, E T30I, M A2V, N A208S, NS3 Q57H, NS7a S83L, NSP2 I21V, NSP2 T85I, NSP4 A307V, NSP12 P323L, NSP13 T115I
2020-12-20 13:19 Andrew Rambaut

I bet that is a chronic patient
2020-12-20 13:20 Andrew Rambaut open

Yes all from the same dead 45 year old man
2020-12-20 13:20 Kristian G. Andersen open

Holy moly - a lot of mutations there...
2020-12-20 13:20 Andrew Rambaut open

Is that the NEJM case?
2020-12-20 13:20 Andrew Rambaut open

Seems to be an increasing number over time.