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Slack / Private Message Drop, p.227 [SLACK_000441] · slack_pm:msg:02358

Date: 2020-10-22 09:32
Type: chat message · slack
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry

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Some of the feline CoVs but not others have a second FCS (also appears due to an insertion) at the S2' cleavage site just upstream of a putative fusion peptide. [shared file(s): image.png]

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2020-10-22 07:52 Robert F. Garry open

In case you haven't seen this; https://www.cnn.com/2020/10/21/politics/coronavirus-lab-theory-yan-bannon-invs/index.html
2020-10-22 07:57 Robert F. Garry open

This alignment shows how insertions in three subgenuses of betacoronaviruses generate FCS and predicted O-linked glycans. SARS-CoV-2 is not a "unicorn." [shared file(s): image.png]
2020-10-22 08:20 Kristian G. Andersen open

That's a nice alignment Bob - yours? Have you looked at the feline coronaviruses too? Some of them have the _exact_ same furin site. E.g., https://www.ncbi.nlm.nih.gov/protein/AIL54259.1?report=genbank&log$=prottop&blast_rank=1&RID =T38N3HVE016 https://www.ncbi.nlm.nih.gov/protein/AIL54258.1?report=genbank&log$=prottop&blast_rank=2&RID =T38N3HVE016 https://www.ncbi.nlm.nih.gov/protein/AIL54263.1?report=genbank&log$=prottop&blast_rank=3&RID =T38N3HVE016
2020-10-22 08:54 Robert F. Garry open

Yes - I did that but anyone could have. Yes beyond some with the PRRAR the feline coronaviruses have interesting divergence including insertions or predicted O-linked glycans at the S1/S2 junction.
2020-10-22 09:32 Robert F. Garry

Some of the feline CoVs but not others have a second FCS (also appears due to an insertion) at the S2' cleavage site just upstream of a putative fusion peptide. [shared file(s): image.png]

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