Slack / Private Message Drop — page 227

[2020-10-22 01:05:51] [Eddie Holmes] I [2020-10-22 01:06:46] [Eddie Holmes] I'll choose Honey Traps please Brian: [shared file(s): Screen Shot 2020-10-22 at 7.01.01 pm.png] [2020-10-22 07:11:05] [Robert Garry] Good choice Eddie! I think this is the break we've been waiting for. If we can get Trump to tweet about how "Proximal Origins authors paid off with CCP honeys," we'll be back at #1 on Altmetric in no time. Now all we need is to get the Gnews boys working their photoshop and made-up email magic. [2020-10-22 07:13:39] [Andrew Rambaut] I think that graphic is one to print and frame [2020-10-22 07:39:48] [Robert Garry] On it! [2020-10-22 07:52:52] [Robert Garry] In case you haven't seen this; https://www.cnn.com/2020/10/21/politics/coronavirus-lab-theory-yan-bannon-invs/index.html [2020-10-22 07:57:16] [Robert Garry] This alignment shows how insertions in three subgenuses of betacoronaviruses generate FCS and predicted O-linked glycans. SARS-CoV-2 is not a "unicorn." [shared file(s): image.png] [2020-10-22 08:20:30] [Kristian Andersen] That's a nice alignment Bob - yours? Have you looked at the feline coronaviruses too? Some of them have the _exact_ same furin site. E.g., https://www.ncbi.nlm.nih.gov/protein/AIL54259.1?report=genbank&log$=prottop&blast_rank=1&RID =T38N3HVE016 https://www.ncbi.nlm.nih.gov/protein/AIL54258.1?report=genbank&log$=prottop&blast_rank=2&RID =T38N3HVE016 https://www.ncbi.nlm.nih.gov/protein/AIL54263.1?report=genbank&log$=prottop&blast_rank=3&RID =T38N3HVE016 [2020-10-22 08:54:45] [Robert Garry] Yes - I did that but anyone could have. Yes beyond some with the PRRAR the feline coronaviruses have interesting divergence including insertions or predicted O-linked glycans at the S1/S2 junction. [2020-10-22 09:32:33] [Robert Garry] Some of the feline CoVs but not others have a second FCS (also appears due to an insertion) at the S2' cleavage site just upstream of a putative fusion peptide. [shared file(s): image.png] [2020-10-22 12:19:21] [Robert Garry]