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Slack / Private Message Drop, pp.212-213 [SLACK_000426] · slack_pm:msg:02212

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I honestly don't know how we're all not dead already... :skull:

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A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2020-10-05 13:50 Edward C. Holmes open

@Kristian Andersen Do you believe the data that "bat SARSr-CoV RBDs showed a higher binding affinity to human ACE2 than to R. sinicus ACE2s". Seems so counter-intuitive.
2020-10-05 14:19 Kristian G. Andersen open

Yeah, they show that particular point using a couple of different assays, so I think probably true. I agree it's a little counter-intuitive, but probably the binding to hACE2 is generally speaking more optimized for binding to the RBD (soit's inherently a higher affinity binding - no matter the RBD).
2020-10-05 15:05 Edward C. Holmes open

Thanks for looking into it. Pretty amazing. Emergence here we come.
2020-10-05 15:17 Kristian G. Andersen

I honestly don't know how we're all not dead already... :skull: