Private channel session 450

4 messages over 1h 27m, 2020-10-05 – 2020-10-05.

A “conversation” here is an activity session — a run of messages with under 60 minutes of silence inside it. The channel had no native conversation boundaries.

2020-10-05 13:50 Edward C. Holmes open PDF p.212

@Kristian Andersen Do you believe the data that "bat SARSr-CoV RBDs showed a higher binding affinity to human ACE2 than to R. sinicus ACE2s". Seems so counter-intuitive.
2020-10-05 14:19 Kristian G. Andersen open PDF p.212

Yeah, they show that particular point using a couple of different assays, so I think probably true. I agree it's a little counter-intuitive, but probably the binding to hACE2 is generally speaking more optimized for binding to the RBD (soit's inherently a higher affinity binding - no matter the RBD).
2020-10-05 15:05 Edward C. Holmes open PDF p.212

Thanks for looking into it. Pretty amazing. Emergence here we come.
2020-10-05 15:17 Kristian G. Andersen open PDF p.212

I honestly don't know how we're all not dead already... :skull: