Chat message

Slack / Private Message Drop, p.212 [SLACK_000426] · slack_pm:msg:02210

Date: 2020-10-05 14:19
Type: chat message · slack
recipient: Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker: Kristian G. Andersen
Topics: Furin cleavage site and molecular features

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Yeah, they show that particular point using a couple of different assays, so I think probably true. I agree it's a little counter-intuitive, but probably the binding to hACE2 is generally speaking more optimized for binding to the RBD (soit's inherently a higher affinity binding - no matter the RBD).

Extracted statements

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Statement	Grade	Attribution	Stance
I agree it's a little counter-intuitive, but probably the binding to hACE2 is generally speaking more optimized for binding to the RBD (soit's inherently a higher affinity binding - no matter the RBD).	needs context	uncertain explicit hedge	acknowledges

Statement

Grade

Attribution

Stance

I agree it's a little counter-intuitive, but probably the binding to hACE2 is generally speaking more optimized for binding to the RBD (soit's inherently a higher affinity binding - no matter the RBD).

needs context

uncertain explicit hedge

acknowledges

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2020-10-05 13:50 Edward C. Holmes open

@Kristian Andersen Do you believe the data that "bat SARSr-CoV RBDs showed a higher binding affinity to human ACE2 than to R. sinicus ACE2s". Seems so counter-intuitive.
2020-10-05 14:19 Kristian G. Andersen

Yeah, they show that particular point using a couple of different assays, so I think probably true. I agree it's a little counter-intuitive, but probably the binding to hACE2 is generally speaking more optimized for binding to the RBD (soit's inherently a higher affinity binding - no matter the RBD).
2020-10-05 15:05 Edward C. Holmes open

Thanks for looking into it. Pretty amazing. Emergence here we come.
2020-10-05 15:17 Kristian G. Andersen open

I honestly don't know how we're all not dead already... :skull:

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