Chat message

Slack / Private Message Drop, p.212 [SLACK_000426] · slack_pm:msg:02206

Date: 2020-10-05 10:57
Type: chat message · slack
mentioned: Edward C. Holmes
recipient: Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker: Kristian G. Andersen
Topics: Furin cleavage site and molecular features

Recipients on this medium are inferred from channel membership, not per-message addressing.

@Eddie Holmes the paper you shared a while back about the ACE2 selection - very interesting and so messed up. Basically, ACE2 in bats and SARS-like CoVs are in a constant evolutionary race swapping AAs frequently. When you combine it with this part (from the paper): "we found that bat SARSr-CoV RBDs showed a higher binding affinityto human ACE2 than to R. sinicus ACE2s but did not display obvious differences among the R. sinicus ACE2s" -well, you'll always have a disaster in the waiting....

Extracted statements

Rule-extracted, not adjudicated. The grade says what may be done with each one; read the document above before relying on any of them.

Statement	Grade	Attribution	Stance
When you combine it with this part (from the paper): "we found that bat SARSr-CoV RBDs showed a higher binding affinityto human ACE2 than to R. sinicus ACE2s but did not display obvious differences among the R. sinicus ACE2s" -well, you'll always have a disaster in the waiting....	quoted / not their view	quoted_external sentence carries quotation marks	asserts

Statement

Grade

Attribution

Stance

When you combine it with this part (from the paper): "we found that bat SARSr-CoV RBDs showed a higher binding affinityto human ACE2 than to R. sinicus ACE2s but did not display obvious differences among the R. sinicus ACE2s" -well, you'll always have a disaster in the waiting....

quoted / not their view

quoted_external sentence carries quotation marks

asserts

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2020-10-05 10:29 Robert F. Garry open

Kayleigh McEnany and 2 others in the WH communications office are positive.
2020-10-05 10:35 Kristian G. Andersen open

Many more to come.
2020-10-05 10:51 Robert F. Garry open

Yeah it's really true that most cases are due to these "super-spreader events." Bad terminology but it's true - a case either doesn't spread or spreads to few or there are many cases all linked.
2020-10-05 10:55 Kristian G. Andersen open

While there are certainly SS events, it's still not clear to me if events like these are due to a person being particularlyprone to spreading, or whether it's just the event itself (in other words - could any standard patient lead to these events, or does it take something special?).
2020-10-05 10:57 Kristian G. Andersen

@Eddie Holmes the paper you shared a while back about the ACE2 selection - very interesting and so messed up. Basically, ACE2 in bats and SARS-like CoVs are in a constant evolutionary race swapping AAs frequently. When you combine it with this part (from the paper): "we found that bat SARSr-CoV RBDs showed a higher binding affinityto human ACE2 than to R. sinicus ACE2s but did not display obvious differences among the R. sinicus ACE2s" -well, you'll always have a disaster in the waiting....
2020-10-05 11:06 Robert F. Garry open

"could any standard patient lead to these events, or does it take something special" It's probably both - put your standard patient in the right situation [like the WH gala or a bar]- they will SS. I also think there are likely special patients that exist that spread especially well and that very high virus load is a major discriminator btwn the standard and special patients.

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