Chat message

Slack / Private Message Drop, p.167 [SLACK_000381] · slack_pm:msg:01716

Date: 2020-09-14 23:41
Type: chat message · slack
recipient: Kristian G. Andersen, Robert F. Garry, Edward C. Holmes
speaker: Andrew Rambaut
Topics: Furin cleavage site and molecular features

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Ooh. Just saw this bit: ```Since many phylogenetic analyses categorize coronaviruses based on the sequence similarity of the RdRp gene only SARS-CoV-2 and ZC45/ZXC21 are separated into different groups/sub-lineages in phylogenetic studies.``` So they are saying 'they' used RdRp from a different virus to confuse phylogenetics!

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2020-09-14 23:40 Kristian G. Andersen open

Well, they do cite your CV, so there's that.
2020-09-14 23:40 Edward C. Holmes open

Do I get a citation?
2020-09-14 23:40 Kristian G. Andersen open

Oh yes
2020-09-14 23:40 Edward C. Holmes open

I'm all for it then.
2020-09-14 23:41 Andrew Rambaut

Ooh. Just saw this bit: ```Since many phylogenetic analyses categorize coronaviruses based on the sequence similarity of the RdRp gene only SARS-CoV-2 and ZC45/ZXC21 are separated into different groups/sub-lineages in phylogenetic studies.``` So they are saying 'they' used RdRp from a different virus to confuse phylogenetics!
2020-09-14 23:41 Kristian G. Andersen open

shared file(s): Screen Shot 2020-09-14 at 11.40.57 PM.png
2020-09-14 23:41 Andrew Rambaut open

Then they constructed RaTG13 with that RdRp as well to act as a decoy.
2020-09-14 23:41 Edward C. Holmes open

Fuck, that's cunning.
2020-09-14 23:41 Andrew Rambaut open

But forgot to put the RBD or furin site in.

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