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Slack / Private Message Drop, p.151 · slack_pm:msg:01546

Date: 2020-08-30 22:51 (hour precision)
Type: chat message · slack
recipient: Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker: Kristian G. Andersen
Topics: Proximal Origin paper

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Probably the most jarring COVID abstract I have read in a paper I just got for review for Nature Medicine: _"Here, from 273 COVID-19 patients, we identified six cases of reinfection based on clinical, phylogenic, virological, serological, and epidemiological data. During the secondary episode, we observed re-emergence of COVID-19 symptoms, new pulmonary lesions on CT images, increased viral load, and secondary humoral immune responses. More importantly, reinfection occurred not only in patients with inadequate or loss of immunity after the primary infection, but also in patients with measurable levels of neutralizing antibodies."_I need to look more carefully tomorrow morning, but on first glance the paper looks solid... This would not be good tosay the least.

Extracted statements

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Statement	Grade	Attribution	Stance
Probably the most jarring COVID abstract I have read in a paper I just got for review for Nature Medicine: _"Here, from 273 COVID-19 patients, we identified six cases of reinfection based on clinical, phylogenic, virological, serological, and epidemiological data.	needs context	uncertain explicit hedge	asserts

Statement

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Attribution

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needs context

uncertain explicit hedge

asserts

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2020-08-30 22:51 Edward C. Holmes open

Had to write a reference for someone EgoHealth and I'm amused to see that they have a 'chief of staff':
2020-08-30 22:51 Edward C. Holmes open

*Aleksei Chmura, PhD* _ Chief of Staff_ EcoHealth Alliance
2020-08-30 22:51 Robert F. Garry open

"Bob and I are now officially in the same 'Family' as the Grand Wizard of EgoHealth." This make me more than a "little bit nauseous," but so be it. I'm looking forward to the in-person meetings.
2020-08-30 22:51 Kristian G. Andersen

Probably the most jarring COVID abstract I have read in a paper I just got for review for Nature Medicine: _"Here, from 273 COVID-19 patients, we identified six cases of reinfection based on clinical, phylogenic, virological, serological, and epidemiological data. During the secondary episode, we observed re-emergence of COVID-19 symptoms, new pulmonary lesions on CT images, increased viral load, and secondary humoral immune responses. More importantly, reinfection occurred not only in patients with inadequate or loss of immunity after the primary infection, but also in patients with measurable levels of neutralizing antibodies."_I need to look more carefully tomorrow morning, but on first glance the paper looks solid... This would not be good tosay the least.
2020-08-30 22:51 Andrew Rambaut open

Are the genomes different? Could these be chronic infections?
2020-08-30 22:51 Andrew Rambaut open

I guess they are different given '_phylogenic'._
2020-08-30 22:51 Kristian G. Andersen open

Yup, different genomes so not relapse
2020-08-30 22:51 Andrew Rambaut open

How are the 273 patients selected. It seems implausible that in most parts of the world 6 out of 273 would even beexposed twice let alone infected.

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