A single line often inverts meaning once you see what it
answers, so neighbouring messages are always shown.
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Thanks! More stuff to wind up Ebright and the others.
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Is this the "Nature Microbiology" paper I have been dodging reporters on today?
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Yeah. Just some phylogenies, recombination and date estimates of SARS related coronaviruses. Nothing you haven't heard already.
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Cool! One interesting thing I got from Trevor though - if he tries to date SARS2 via the related viruses (of which we now have a few), he gets a relatively nice signal for 2014/2015. Doesn't mean anything in isolation, but I still keepcontemplating that 'pre' circulation scenario for emergence. They need to go hunt some more viruses in those Yunnan caves!
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2020-07-27 14:40
Andrew Rambaut
It is meaningless to date SARS2 with related viruses - makes no sense.
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I thought so too, but honing in on specific parts of the genomes that were homologous it seemed like it could bedone - no idea about the details though.
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It also makes no sense that the SARS2 diversity circulating now was part of the pre-circulating scenario. The Wuhanhaplotype may have been around for a month or two prior to Dec 2019 but not much longer given the transmissibilityof the virus. This virus doesn't lurk unobserved.
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Has Trevor found his next thing to go off on Twitter about?
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"This virus doesn't lurk unobserved" - as is, definitely true - but I _do_ wonder if a pre-furin site virus could. But Iagree with you - I'm not sure such an analysis makes sense given our limited sampling. Assuming SARS2 came outof Yunnan diversity (which seems likely), it would be cool to go do some in-depth sampling from there. And yes, maybe we'll get the big reveal on Twitter :wink: