Kristian G. Andersen M
Engagement
| Authored | 1 |
| Substantive (25+ words) | 1 |
| Threads posted in | 0 |
| Distinct active days | 1 |
| Words authored | 1,424 |
| Received (incl. group broadcast) | 0 |
Received counts include every message sent to a channel this
person belonged to. That measures presence, not participation.
Statements
- 0 own voice
- 0 need context
- 13 quoted / not their view
13 sentences were extracted and attributed
to this person. Most are not their own opinion. Reporting the total as
“13 statements” would misrepresent them.
Correspondents
Topics
Appears in
Statement record
Showing:
own voice, substantive
needs context
quoted / not their view
all
2020-03-06
quoted / not their view
draft_language · reports · email
Andersen Coronavirus Nature Medicine Press Release Draft 2-24-20 The COVID-19 coronavirus epidemic has a natural origin, scientists say The novel SARS-CoV-2 coronavirus that emerged in the city of Wuhan, China, last year and has since caused a large scale COVID-19 epidemic and spread to more than 70 other countries is the product of natural evolution, according to findings published today in the journal Nature Medicine.
Fauci Intelligence Community Release, p.39 · original PDF
· in context
2020-03-06
quoted / not their view
quoted_external · asserts · email
More specifically, they focused on two important features of the spike protein: the receptor-binding vu domain (RBD), a kind of grappling hook that grips onto host cells, and the cleavage site, a molecular can opener that allows the virus to crack open and enter host cells.
Fauci Intelligence Community Release, p.39 · original PDF
· in context
2020-03-06
quoted / not their view
quoted_external · asserts · email
Evidence for natural evolution The scientists found that the RBD portion of the SARS-CoV-2 spike proteins had evolved to effectively target a molecular feature on the outside of human cells called ACE2, a receptor involved in regulating blood pressure.
Fauci Intelligence Community Release, p.39 · original PDF
· in context
2020-03-06
quoted / not their view
quoted_external · asserts · email
The SARS-CoV-2 spike protein was so effective at binding the human cells, in fact, that the scientists concluded it was the result of natural selection and not the product of genetic engineering.
Fauci Intelligence Community Release, p.39 · original PDF
· in context
2020-03-06
quoted / not their view
quoted_external · asserts · email
But the scientists found that the SARS-CoV-2 backbone differed substantially from those of already known coronaviruses and mostly resembled related viruses found in bats and pangolins.
Fauci Intelligence Community Release, p.39 · original PDF
· in context
2020-03-06
quoted / not their view
quoted_external · denies · email
"These two features of the virus, the mutations in the RBD portion of the spike protein and its distinct backbone, rules out laboratory manipulation as a potential origin for SARS-CoV-2" said Andersen.
Fauci Intelligence Community Release, p.39 · original PDF
· in context
2020-03-06
quoted / not their view
quoted_external · asserts · email
There are no documented cases of direct bat-human transmission, however, suggesting that an intermediate host was likely involved between bats and humans.
Fauci Intelligence Community Release, p.39 · original PDF
· in context
2020-03-06
quoted / not their view
hypothetical · asserts · email
In this scenario, both of the distinctive features of SARS-CoV-2's spike protein--the RBD portion that binds to cells and the cleavage site that opens the virus up--would have evolved to their current state prior to entering humans.
Fauci Intelligence Community Release, p.39 · original PDF
· in context
2020-03-06
quoted / not their view
quoted_external · asserts · email
For instance, some coronaviruses from pangolins, armadillo-like mammals found in Asia and Africa, have an RBD structure very similar to that of SARS-CoV-2.
Fauci Intelligence Community Release, p.39 · original PDF
· in context
2020-03-06
quoted / not their view
quoted_external · asserts · email
A coronavirus from a pangolin could possibly have been transmitted to a human, either directly or through an intermediary host such as civets or ferrets.
Fauci Intelligence Community Release, p.39 · original PDF
· in context
2020-03-06
quoted / not their view
hypothetical · asserts · email
Then the other distinct spike protein characteristic of SARS-CoV-2, the cleavage site, could have evolved within a human host, possibly via limited undetected circulation in the human population prior to the beginning of the epidemic.
Fauci Intelligence Community Release, p.39 · original PDF
· in context
2020-03-06
quoted / not their view
quoted_external · asserts · email
The researchers found that the SARS-CoV-2 cleavage site, appears similar to the cleavage sites of strains of bird flu that has been shown to transmit easily between people.
Fauci Intelligence Community Release, p.39 · original PDF
· in context
2020-03-06
quoted / not their view
hypothetical · asserts · email
SARS-CoV-2 could have evolved such a virulent cleavage site in human cells and soon kicked off the current epidemic, as the coronavirus would possibly have become far more capable of spreading between people.
Fauci Intelligence Community Release, p.39 · original PDF
· in context