Slack / Private Message Drop — page 712

[Robert Garry] T80A if I have counted right. The other NSP mutations are in A.23.1. NSP6: L98F, M83I, M86I. A.23.1 used Q613H and Y346H to open the door instead of PhiL and DouG. [2021-04-16 12:09:50] [Robert Garry] WELL it's T77A - I didn't count right the first time. [2021-04-16 12:12:20] [Robert Garry] shared file(s): image.png [2021-04-16 12:23:58] [Kristian Andersen] Interesting - 77 is pretty buried, so may not really play a role. [2021-04-16 12:32:44] [Robert Garry] Actually I think that TM domain is probably doing some "business." I wouldn't discount some sort of "channel" activity so the T to A change could make a difference. [2021-04-16 12:33:47] [Robert Garry] Remodeling lipids is another possibility. [2021-04-16 13:28:50] [Eddie Holmes] Attacked by Tucker Carlson - badge of honour Bob. China are definitely not trying hard to get the bottom of the lab because they've ruled that out already. [2021-04-16 13:38:29] [Kristian Andersen] I think they're perfectly contend with the Americans running around in circles and falling over themselves talking about lab escapes. [2021-04-16 13:43:46] [Robert Garry] Good points! [2021-04-16 13:50:14] [Eddie Holmes] I agree! [2021-04-17 06:39:31] [Robert Garry] Having "conquered" the "origin" of SC2 DRASTIC turns its "arsenal" on another possible "lab leak." Seemingly it's timely to relitigate the CHAT-OPV hypothesis. If there's just a 1% chance HIV is a "lab leak" shouldn't we shut down all the virologists? [shared file(s): image.png] [2021-04-17 06:51:51] [Robert Garry] It was Tom Curtis of The Rolling Stone that birthed the notion that HIV was a "lab leak." The last paragraph is prophetic - blame the virologists. "Like Salk and Sabin, Koprowski had the best intentions: He wanted to eradicate a debilitating and deadly scourge. But with what we know now, it's clear there was a certain hubris involved in the rough-and-ready campaigns to conquer polio. There is evidence that all three pioneers used vaccines inadvertently contaminated with viruses from a species dangerously close to our own. If the Congo vaccine turns out not to be the