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Slack / Private Message Drop, pp.711-712 [SLACK_000925] · slack_pm:msg:07466

Page text: p.711, p.712 · original PDF

Date
2021-04-16 11:58
Type
chat message · slack
recipient
Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker
Robert F. Garry

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T80A if I have counted right. The other NSP mutations are in A.23.1. NSP6: L98F, M83I, M86I. A.23.1 used Q613H and Y346H to open the door instead of PhiL and DouG.

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  1. 2021-04-16 11:26 Kristian G. Andersen open
    Eek, Jr - love it :wink:. the del3675/77 is the nsp6 deletion, correct?
  2. 2021-04-16 11:31 Robert F. Garry open
    I think that's correct. Also, the nonbat "mutations in" Spike (A372 - knocks out a glycosylation site and H519) likely give SC2 a leg up - ie maybe makes it more pan-tropic. Of course need to mention the PRRA nonbat insertion too.
  3. 2021-04-16 11:39 Robert F. Garry open
    I think this is the NSP6 mutation in B.1.617 [shared file(s): image.png]
  4. 2021-04-16 11:48 Kristian G. Andersen open
    Which one in that figure?
  5. 2021-04-16 11:58 Robert F. Garry
    T80A if I have counted right. The other NSP mutations are in A.23.1. NSP6: L98F, M83I, M86I. A.23.1 used Q613H and Y346H to open the door instead of PhiL and DouG.
  6. 2021-04-16 12:09 Robert F. Garry open
    WELL it's T77A - I didn't count right the first time.
  7. 2021-04-16 12:12 Robert F. Garry open
    shared file(s): image.png
  8. 2021-04-16 12:23 Kristian G. Andersen open
    Interesting - 77 is pretty buried, so may not really play a role.
  9. 2021-04-16 12:32 Robert F. Garry open
    Actually I think that TM domain is probably doing some "business." I wouldn't discount some sort of "channel" activityso the T to A change could make a difference.

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