Slack / Private Message Drop — page 464

Good for you! [2021-01-29 16:39:11] [Kristian Andersen] Petrovsky is SUCH an idiot - in the literal sense. [2021-01-29 16:42:07] [Eddie Holmes] Totally. I remember now that I was asked to do this but declined. I'm still pretty shocked by Alina's tweet [2021-01-29 18:48:38] [Robert Garry] The producer kept saying I did great - we'll see... [2021-01-29 18:50:18] [Robert Garry] Alina is totally inappropriate...she and Petrovsky - not that different. [2021-01-29 19:07:13] [Eddie Holmes] I'm sure you were great! At least Petrovsky is trying to do something positive re the vaccine. Alina is just negative and destructive. [2021-01-29 23:30:25] [Eddie Holmes] CONFIDENTIAL from Weifeng. The full-length tree is clearly not very informative. Very complex recombination. The RdRp tree looks clean perhaps. Apparently the China CDC also have a virus that is 91% similar. I don't have the sequences yet, but I have a plan. [shared file(s): Bat-CoV 20210130.pptx] [2021-01-30 02:30:14] [Robert Garry] Thanks - This is terrific and a huge amount of work. The differences in nucleotide and amino acid trees in spike and RBD seem to have attracted some attention, which is good. Would like to see a similar analysis of NTD, etc [esp NTD ] like @Andrew Rambaut did in Boni2020. [2021-01-30 02:43:17] [Eddie Holmes] Good idea. The alphas are really interesting as well. [2021-01-30 03:01:22] [Andrew Rambaut] [thread - ID: 2021-01-29 16:24:34] @Robert Garry Bates Gill is an excellent spoonerism of Bill Gates. I wonder what the tin-foils will make of that? [2021-01-30 05:40:40] [Robert Garry] [thread - ID: 2021-01-30 05:40:40] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241398/#mmc1 This is the Baric/Shi cell paper on ACE2 trangenics that the DRASTIC crowd is obsessing over. This caught my attention: "The lung isolates indicated two mutations, C14554T (nsp13, L372F) and C23525T (spike, H644Y), compared with the genome of SARS-CoV-2-WIV04 (GISAID: EPI_ISL_402124). The mutation at nsp13 was unique compared with published viral sequences identified by online BLAST. The mutation in the spike gene was located at the end of the S1 region of the spike gene. This mutation was identified using BLAST in SARS-CoV-2 genome sequence isolated from a patient from the United States (GenBank: MT163720). The brain isolates exhibited only one mutation, C23525T (H644Y), at the S1 region of the spike gene." Nobody is perfect and they got the amino acid number wrong. No histadine at 644. C23525T is actually H655Y! You'll recognize that as one of the P.1 mutations.