Slack / Private Message Drop — page 420

inventiveness of its language.[3][4][5] [2021-01-18 17:50:42] [Robert Garry] Seems like it might be a good source for VoC names though. [2021-01-18 18:05:38] [Eddie Holmes] Excellent idea! I remember trying to read Vox years ago and giving up. [2021-01-18 19:11:57] [Robert Garry] You may have picked the wrong book of the trilogy https://www.gq.com/story/nicholson-baker-house-holes-book-review "The dirtiest mind in American lit, Nicholson Baker, overshoots with his Seussian smutfest _House of Holes_ How has the English language done without _fuckwizard, manslurp,_and _thundertube?..."_ [2021-01-18 19:15:34] [Robert Garry] Thanks for the hard work on the post Eddie -looking great and will be happy to move you anywhere on the list per @Kristian Andersen... [2021-01-18 19:18:59] [Kristian Andersen] Let's move Eddie to the back - makes much more sense, plus I'm an amateur when it comes to this type of stuff - let's make sure you have the bonafide expert to back you up... :wink: [2021-01-18 20:13:49] [Eddie Holmes] On the deletions delH69 and delV70. I've cut been chatting with Tommy Lam and he says that for the Guangxi pangos they have two viruses: the original sample from the lung has a deletion of these two amino acids. However, the vero cell isolate does not (i.e. has the insertion). Make sense? [2021-01-18 21:17:14] [Kristian Andersen] That seems strange... Random insertion in T/C or what you'd see in e.g., SC2? It's not the other way around? [2021-01-18 21:30:00] [Eddie Holmes] I'm pretty sure that's what he said and I was also surprised. I'll double check. [2021-01-18 21:33:28] [Kristian Andersen] That seems really weird - I have a hard time seeing how it could gain an ancestral insert via passage. HOWEVER, it's possible you have both viruses in the isolate - one major without the insert and one minor with. Then once you passage, the one with the insert rapidly outcompetes the other. If what you're saying is indeed correct, then I think this is the most likely explanation [2021-01-18 21:52:33] [Eddie Holmes] Yes, I had the same thought. [2021-01-19 00:24:28] [Eddie Holmes] From Tommy: