Chat message

Slack / Private Message Drop, p.420 [SLACK_000634] · slack_pm:msg:04351

Date: 2021-01-18 21:33
Type: chat message · slack
recipient: Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker: Kristian G. Andersen

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That seems really weird - I have a hard time seeing how it could gain an ancestral insert via passage. HOWEVER, it's possible you have both viruses in the isolate - one major without the insert and one minor with. Then once you passage, the one with the insert rapidly outcompetes the other. If what you're saying is indeed correct, then I think this is the most likely explanation

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-01-18 21:17 Kristian G. Andersen open

That seems strange... Random insertion in T/C or what you'd see in e.g., SC2? It's not the other way around?
2021-01-18 21:30 Edward C. Holmes open

I'm pretty sure that's what he said and I was also surprised. I'll double check.
2021-01-18 21:33 Kristian G. Andersen

That seems really weird - I have a hard time seeing how it could gain an ancestral insert via passage. HOWEVER, it's possible you have both viruses in the isolate - one major without the insert and one minor with. Then once you passage, the one with the insert rapidly outcompetes the other. If what you're saying is indeed correct, then I think this is the most likely explanation
2021-01-18 21:52 Edward C. Holmes open

Yes, I had the same thought.

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