Slack / Private Message Drop — page 3

I don't follow - "The mutation Spike D614G is of urgent concern". Frankly, my concern over the virus has not really changed one jot over this mutation. D614 was associated with a huge epidemic in China that was only controlled through a severe lockdown and don't see any difference in G614. [2020-05-01 02:51:12] [Andrew Rambaut] Yes. It is bollocks. Looking at the Sheffield clinical data too - very weak. We are preparing a rebuttal based on the UK data. This paper will be going to Science I would imagine. Would be good to rebut it before review. [2020-05-01 02:58:03] [Eddie Holmes] [thread - ID: 2020-05-01 02:58:03] Cell I believe. Get your retaliation in first. Excellent. [2020-05-01 03:00:42] [Eddie Holmes] This one is a corker. I noticed it because MaRNAV-1 is my Plasmodium narnavirus of which I am very proud. No need to read beyond the 3rd paragraph of the Abstract: [shared file(s): Mehta2020.pdf] [2020-05-01 04:53:22] [Robert Garry] From Korber2020 "Thus, this mutation might be conferring resistance to protective D614-directed antibody responses in infected people, making them more susceptible to reinfection with the newer G614 form of the virus. Alternatively, the advantage might be related to the fact that D614 is embedded in an immunodominant ADE epitope of SARS-CoV (Wang et al., 2016), and perhaps the G614 form can facilitate ADE." This part is "bollocks." Reinfection - not happening. ADE during a primary infection? There are indeed some "funny" things about the antibody responses to NCoV-19, but this is way way out on a very thin limb. [2020-05-01 07:49:21] [Andrew Rambaut] UK clusters by duration: [shared file(s): image.png] [2020-05-01 07:50:08] [Andrew Rambaut] and numbers of sequences: [shared file(s): image.png] [2020-05-01 07:51:05] [Andrew Rambaut] [thread - ID: 2020-05-01 02:58:03] @Eddie Holmes Yes. Funny that - just got it to review. Will turn it down (on the basis I am already writing a rebuttal to their preprint). [2020-05-01 08:23:13] [Kristian Andersen] Clearly no difference... [2020-05-01 08:26:59] [Andrew Rambaut] ```Ref.: Ms. No. THEIJID-D-20-01291 The 5' UTR of SARS-CoV-2 seems to be genetically unique; implications for improved molecular diagnostics and treatment strategies International Journal of Infectious Diseases Dear Professor Rambaut, You may remember that on 22 Apr 2020 I asked if you would be able to review the above manuscript for us. I have