Chat message

Slack / Private Message Drop, p.3 [SLACK_000217] · slack_pm:msg:00017

Page text: p.3 · original PDF

Date: 2020-05-01 07:49
Type: chat message · slack
recipient: Kristian G. Andersen, Robert F. Garry, Edward C. Holmes
speaker: Andrew Rambaut

Recipients on this medium are inferred from channel membership, not per-message addressing.

UK clusters by duration: [shared file(s): image.png]

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2020-05-01 07:49 Andrew Rambaut

UK clusters by duration: [shared file(s): image.png]
2020-05-01 07:50 Andrew Rambaut open

and numbers of sequences: [shared file(s): image.png]
2020-05-01 07:51 Andrew Rambaut open

@Eddie Holmes Yes. Funny that - just got it to review. Will turn it down (on the basis I am already writing a rebuttalto their preprint).
2020-05-01 08:23 Kristian G. Andersen open

Clearly no difference...
2020-05-01 08:26 Andrew Rambaut open

```Ref.: Ms. No. THEIJID-D-20-01291 The 5' UTR of SARS-CoV-2 seems to be genetically unique; implications for improved molecular diagnostics and treatment strategies International Journal of Infectious Diseases Dear Professor Rambaut, You may remember that on 22 Apr 2020 I asked if you would be able to review the above manuscript for us. I have not yet heard from you and would ask you to let us know as soon as possible whether or not you will be able to dothis for us.The manuscript abstract appears below.In our paper we describe some unusual characteristics of the regulatory 5' UTR sequences of SARS-CoV-2 that might imply its non-natural origin. Moreover, we have developed and internally validated a robust, sensitive and specific quantitative Real-Time PCR assay targeting this very unique part of the SARS-CoV-2 genome, which wehave been using for routine diagnostics instead of the original, N gene targeting protocol; our 5' UTR-targetingprotocol can be found in the Supplementary material of this paper. We are also discussing possible therapeuticimplications of this finding - especially RNA interference and direct knock-out of the unique 5' UTR regulatory sequences of the SARS-CoV-2 virus, which, due to the high replication (and error) rate of SARS-CoV-2 might besuperior to the development of conventional immunogenic vaccines and might be an interesting idea to pursue.```5' UTR apparently has a non-natural origin.

Full conversation →