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Slack / Private Message Drop, p.3 [SLACK_000217] · slack_pm:msg:00016

Page text: p.3 · original PDF

Date
2020-05-01 04:53
Type
chat message · slack
recipient
Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker
Robert F. Garry

Recipients on this medium are inferred from channel membership, not per-message addressing.

From Korber2020 "Thus, this mutation might be conferring resistance to protective D614-directed antibody responses in infected people, making them more susceptible to reinfection with the newer G614 form of the virus. Alternatively, the advantage might be related to the fact that D614 is embedded in an immunodominant ADE epitopeof SARS-CoV (Wang et al., 2016), and perhaps the G614 form can facilitate ADE." This part is "bollocks." Reinfection - not happening. ADE during a primary infection? There are indeed some "funny" things about the antibody responses to NCoV-19, but this is way way out on a very thin limb.

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  1. 2020-05-01 04:53 Robert F. Garry
    From Korber2020 "Thus, this mutation might be conferring resistance to protective D614-directed antibody responses in infected people, making them more susceptible to reinfection with the newer G614 form of the virus. Alternatively, the advantage might be related to the fact that D614 is embedded in an immunodominant ADE epitopeof SARS-CoV (Wang et al., 2016), and perhaps the G614 form can facilitate ADE." This part is "bollocks." Reinfection - not happening. ADE during a primary infection? There are indeed some "funny" things about the antibody responses to NCoV-19, but this is way way out on a very thin limb.

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