Baric Transcribed Interview (Redacted) — page 16

DC.Scheduling@LexitasLegal.com worked with. DR. BARIC: Oh, we compared it to a killed vaccine. We'd also tested alpha virus-based vaccines, Venezuelan equine encephalitis replicon particles. It was basically an RNA virus where the structural genes have been removed, so it's single hit. It can only infect one set of cells. It delivers the payload gene, in this case the coronavirus antigen. That induces an immune response that is either protective or not, depending on the model system. The other was killed vaccines. In 2003, the NIH had purchased two, or the Federal Government had purchased two $20 million killed vaccines to test against SARS coronavirus. MS. SALAZAR: What's a killed vaccine? DR. BARIC: They took the SARS coronavirus and then they inactivated it with a chemical inactivation, a UV light. So they killed the virus so that all that was left was the antigenic preparation, and that's put in the animal. So killed vaccines are pretty commonly used in humans. MS. SALAZAR: Okay. And the vaccine, the MERS vaccine, is that the CisVax [sic] vaccine that I saw in one of your grant proposals, was called CisVax? DR. BARIC: CisVax? MS. SALAZAR: I think. If you don't know.