COVID-19 Records

Transcript segment

Baric Transcribed Interview (Redacted), p.16 · baric_ti:utt:00071

Page text: p.16 · original PDF

Date
2026-04-10 09:00 (day precision)
Type
transcript segment · interview
recipient
Christina Salazar, Harry Kazenoff, David T. Lambeth III, William Henderson, Clark Ervin, Jake Greenberg
speaker
Ralph S. Baric
Topics
Vaccines
Oh, we compared it to a killed vaccine. We'd also tested alpha virus-based vaccines, Venezuelan equine encephalitis replicon particles. It was basically an RNA virus where the structural genes have been removed, so it's single hit. It can only infect one set of cells. It delivers the payload gene, in this case the coronavirus antigen. That induces an immune response that is either protective or not, depending on the model system. The other was killed vaccines. In 2003, the NIH had purchased two, or the Federal Government had purchased two $20 million killed vaccines to test against SARS coronavirus.

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In 2003, the NIH had purchased two, or the Federal Government had purchased two $20 million killed vaccines to test against SARS coronavirus. own voice, substantive speaker_own asserts

In context

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  1. 2026-04-10 09:00 Ralph S. Baric open
    Yeah. Moderna certainly was engaged. Whether they actually manufactured the vaccine that was put in the animals or not, or whether NIH made that vaccine and put it in, I don't know.
  2. 2026-04-10 09:00 Christina Salazar open
    And your vaccine, what was it called?
  3. 2026-04-10 09:00 Ralph S. Baric open
    Oh, the Moderna vaccine?
  4. 2026-04-10 09:00 Christina Salazar open
    No, no, no. Yours, the one that you had DC.Scheduling@LexitasLegal.com worked with.
  5. 2026-04-10 09:00 Ralph S. Baric
    Oh, we compared it to a killed vaccine. We'd also tested alpha virus-based vaccines, Venezuelan equine encephalitis replicon particles. It was basically an RNA virus where the structural genes have been removed, so it's single hit. It can only infect one set of cells. It delivers the payload gene, in this case the coronavirus antigen. That induces an immune response that is either protective or not, depending on the model system. The other was killed vaccines. In 2003, the NIH had purchased two, or the Federal Government had purchased two $20 million killed vaccines to test against SARS coronavirus.
  6. 2026-04-10 09:00 Christina Salazar open
    What's a killed vaccine?
  7. 2026-04-10 09:00 Ralph S. Baric open
    They took the SARS coronavirus and then they inactivated it with a chemical inactivation, a UV light. So they killed the virus so that all that was left was the antigenic preparation, and that's put in the animal. So killed vaccines are pretty commonly used in humans.
  8. 2026-04-10 09:00 Christina Salazar open
    Okay. And the vaccine, the MERS vaccine, is that the CisVax [sic] vaccine that I saw in one of your grant proposals, was called CisVax?
  9. 2026-04-10 09:00 Ralph S. Baric open
    CisVax?

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