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1. 2021-09-21 08:01 Kristian G. Andersen open
   IMO we really _do_ need to take a close look at what's described in this grant and look back at our (now expanded)alignments to see if anything pops up. E.g., Bob mentioned that there are differences in Laos bat vs SC2 when itcomes to N-linked glycans, which isn't particularly reassuring - that's the kind of work described on page 11.
2. 2021-09-21 08:05 Andrew Rambaut open
   I agree - need to stay on top of this.
3. 2021-09-21 08:05 Kristian G. Andersen open
   Yes - this can't (shouldn't) be dismissed out of hand.
4. 2021-09-21 08:06 Andrew Rambaut open
   If there is anything suspicious - better that we say it and then address it. If there isn't then we can let it blow over.
5. 2021-09-21 08:06 Kristian G. Andersen
   Exactly. I suspect it'll be the latter.
6. 2021-09-21 08:08 Andrew Rambaut open
   Me too. But it really isn't beyond plausibility that someone went ahead and tried some of this stuff. We just need tore-convince ourselves it is coincidence.
7. 2021-09-21 08:10 Kristian G. Andersen open
   Correct - that's the problem. There's a big difference between "the lab was working on bat CoVs" to "the lab wasmodifying bat CoVs using features we see being unique to SC2".
8. 2021-09-21 08:10 Andrew Rambaut open
   Key question is - would anyone chose to put the FCS we see in SC2 in and put it out of frame.
9. 2021-09-21 08:11 Kristian G. Andersen open
   Would be a very strange way to do it, but not impossible - depending on their cloning strategy.

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