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Slack / Private Message Drop, p.964 [SLACK_001178] · slack_pm:msg:10038

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I'll ponder it...

In context

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2021-06-25 15:10 Edward C. Holmes open

This paper is saying that B.1.1.7 is itself a recombinant
2021-06-25 15:10 Andrew Rambaut open

It also doesn't cite our original virological post https://virological.org/t/563 which gives a suggestion of how it arose (not stepwise)
2021-06-25 15:11 Andrew Rambaut open

It isn't a recombinant.
2021-06-25 15:11 Andrew Rambaut open

But I don't care really - it won't get anywhere
2021-06-25 15:12 Edward C. Holmes

I'll ponder it...
2021-06-25 15:12 Kristian G. Andersen open

I'd reject it - if they then come back, it can go online. But the methods are incorrect.
2021-06-25 15:12 Andrew Rambaut open

There are some intermediates but we believe they are sequences of mixtures (we can look at the BAM files - they are all one ENA unlike the Wuhan genomes)
2021-06-25 15:13 Andrew Rambaut open

I think they have found some dodgy sequence. Jotun Hein also sent us a preprint which claimed to have discovereda recombinant but when we looked, the negative control for that plate was hooching with reads.
2021-06-25 15:14 Andrew Rambaut open

They need to check the raw data (which is available)