Chat message

Slack / Private Message Drop, p.940 [SLACK_001154] · slack_pm:msg:09784

Date: 2021-06-11 16:20
Type: chat message · slack
recipient: Kristian G. Andersen, Robert F. Garry, Andrew Rambaut
speaker: Edward C. Holmes
Topics: Natural origin / zoonotic spillover

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Not only did we know NOTHING about pangolin CoVs until the end of 2019 but we knew NOTHING about pangolin viruses. Period. Now it turns about they are balls of scales full of viruses. The narrative that these are just transientspillover infections is clearly wrong. They can be reservoirs. Whether these MERS-like viruses are of any importance is unclear, but it does show that pangolins are more important in the ecology of these viruses than wethought.

Extracted statements

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Statement	Grade	Attribution	Stance
Not only did we know NOTHING about pangolin CoVs until the end of 2019 but we knew NOTHING about pangolin viruses.	own voice, substantive	speaker_own	asserts
Whether these MERS-like viruses are of any importance is unclear, but it does show that pangolins are more important in the ecology of these viruses than wethought.	needs context	speaker_own	questions

Statement

Grade

Attribution

Stance

Not only did we know NOTHING about pangolin CoVs until the end of 2019 but we knew NOTHING about pangolin viruses.

own voice, substantive

speaker_own

asserts

Whether these MERS-like viruses are of any importance is unclear, but it does show that pangolins are more important in the ecology of these viruses than wethought.

needs context

speaker_own

questions

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-06-11 15:41 Edward C. Holmes open

For the smaller group only...I've heard there are MERS-like viruses in the pangolins. I assume these have a furin cleavage site. Trying to find out what the sequence is.
2021-06-11 15:45 Robert F. Garry open

bingo
2021-06-11 15:58 Kristian G. Andersen open

Ohhh, interesting. I'm so confused about this pangolin stuff - did we always know they were full of CoVs? To me it's something we only found out recently, but I'm not that well-read in this space.
2021-06-11 16:20 Edward C. Holmes

Not only did we know NOTHING about pangolin CoVs until the end of 2019 but we knew NOTHING about pangolin viruses. Period. Now it turns about they are balls of scales full of viruses. The narrative that these are just transientspillover infections is clearly wrong. They can be reservoirs. Whether these MERS-like viruses are of any importance is unclear, but it does show that pangolins are more important in the ecology of these viruses than wethought.
2021-06-11 16:20 Robert F. Garry open

worth doing a closer look - HKU5 CAIPPTTSTRFRRATSGVSDV has a maximum FCS and its on the same branch as MERS CALPDTPSTLTPRSVRSVPGEM. HKU4 also there cavppvstfrs ysasqfqlav, but looking a lot like RmYN02 - so I guess we need asshat Yuri to help with the alignment.
2021-06-11 16:21 Robert F. Garry open

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0236971 this new from PREDICT2 - partial sequences but the tree is interesting

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