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Slack / Private Message Drop, p.887 [SLACK_001101] · slack_pm:msg:09198

Date: 2021-05-27 19:37
Type: chat message · slack
recipient: Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker: Kristian G. Andersen

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I didn't know this bit either: "Still, the fact that viruses in the Yunnan clade (consisting of RmYN02, RpYN06 and PrC31) were sampled from three different Rhinolophus species supports the hypothesis that these viruses readily infect multiple differenthorseshoe bat species with overlapping geographical ranges."Didn't realize they were different species of bats - but, of course, I should, since the naming gives it away.

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-05-27 19:15 Edward C. Holmes open

Useful preprint from David online
2021-05-27 19:20 Kristian G. Andersen open

Yeah, just reading it...
2021-05-27 19:23 Edward C. Holmes open

Says the same as our Cell paper re: RaTG13.
2021-05-27 19:35 Robert F. Garry open

Found this highly interesting: "One possible recent disruption that caused widespread and unusual movements of animals in China and may have increased the permeability of this barrier, was the dramatic shortage of pork products in 2019 attributable to an African swine fever virus (ASFV) outbreak impacting 100s of millions of pigs inChina38. Such a major disruption in the food supply chain will have potentially brought humans into increased contact with Sarbecovirus infected animals as i) exotic meats replaced pork, ii) animals from rural locations were brought to city markets and/or iii) by meat from infected animals being transported in cold chain processes."
2021-05-27 19:37 Kristian G. Andersen

I didn't know this bit either: "Still, the fact that viruses in the Yunnan clade (consisting of RmYN02, RpYN06 and PrC31) were sampled from three different Rhinolophus species supports the hypothesis that these viruses readily infect multiple differenthorseshoe bat species with overlapping geographical ranges."Didn't realize they were different species of bats - but, of course, I should, since the naming gives it away.
2021-05-27 19:43 Robert F. Garry open

Figuring out how the viruses expand their host range even further would be key. Of course, that would require making chimeras which the bloomshitters would frown upon.
2021-05-27 19:45 Kristian G. Andersen open

I found the link to the host range of pangolins quite interesting... https://www.iucnredlist.org/species/12764/168392151
2021-05-27 19:48 Kristian G. Andersen open

Eddie's point that the nearest virus to SARS-CoV-2 isn't actually one that WIV has also needs repeating! [shared file(s): Recombination tree.png]
2021-05-27 20:27 Edward C. Holmes open

Not to moan too much, but we said all this in our Cell paper (there's even a whole section on host range mapping).Probably good that it is being said again though.

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