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Slack / Private Message Drop, p.759 [SLACK_000973] · slack_pm:msg:07945

Date: 2021-05-07 05:24
Type: chat message · slack
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry

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```iNQTdlfefvNhTQprrarrSSntqnvqty``` The cat FCS is _actually_ even more SC2 like. It has a QTQTNSP "like" [QTN are polar uncharged amino acids] landing site prior to the FCS and the two SERINES are predicted O-linked glycan sites. As you said @Kristian Andersen - an act of nature not an act of man [or woman].

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2021-05-07 05:24 Robert F. Garry

```iNQTdlfefvNhTQprrarrSSntqnvqty``` The cat FCS is _actually_ even more SC2 like. It has a QTQTNSP "like" [QTN are polar uncharged amino acids] landing site prior to the FCS and the two SERINES are predicted O-linked glycan sites. As you said @Kristian Andersen - an act of nature not an act of man [or woman].
2021-05-07 05:44 Robert F. Garry open

https://scitechdaily.com/tracing-covid-back-to-origin-many-variant-strains-were-alrea[...]dy-present-before-the-first-known-cases-identified-in-china/
2021-05-07 05:46 Robert F. Garry open

I'm not convinced.
2021-05-07 06:21 Robert F. Garry open

Here is Wade's quote on the FCS. "Viruses have all kinds of clever tricks, so why does the furin cleavage site stand out? Because of all known SARS-related beta-coronaviruses, only SARS2 possesses a furin cleavage site. All the other viruses have their S2 unit cleaved at a different site and by a different mechanism." It's of course a "clever trick," and misleading at best. Other betacoronaviruses (MERS, HKU5, HKU1, OC43, HKU24https://www.sciencedirect.com/science/article/pii/S1873506120304165;https://virological.org/t/naturally-occurring-indels-in-multiple-coronavirus-spikes/560) and a plethora of other viruses (flu, HIV, parmyxoviruses to name just a few) use FCS in the same way as SC2.
2021-05-07 06:21 Robert F. Garry open

https://www.buzzsprout.com/1016881/8471236

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