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Slack / Private Message Drop, p.738 [SLACK_000952] · slack_pm:msg:07728

Date: 2021-04-30 06:32
Type: chat message · slack
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry

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Very important point - IF you were engineering in a FCS why use an out-of-frame insertion, add a freaking proline infront (unless you somehow were aware that that would help create the mystical O-linked glycans] and put in aminimal/suboptimal FCS (RXXR, instead of the optimal RXRR)? PooH and PooR are still trying to "get it right."

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2021-04-30 06:32 Robert F. Garry

Very important point - IF you were engineering in a FCS why use an out-of-frame insertion, add a freaking proline infront (unless you somehow were aware that that would help create the mystical O-linked glycans] and put in aminimal/suboptimal FCS (RXXR, instead of the optimal RXRR)? PooH and PooR are still trying to "get it right."
2021-04-30 06:35 Robert F. Garry open

https://www.lemonde.fr/planete/article/2021/04/30/origines-du-sars-cov-2-des-scienti[...]gnent-a-l-oms-d-eclaircir-les-zones-d-ombre_6078611_3244.html
2021-04-30 07:00 Andrew Rambaut open

I should say that 'suboptimal' in terms of cleavage may be optimal in terms of transmission (i.e., getting the right level of viral shedding in the right tissues at the right time given the behaviour of the human population) . But no way someone would be able predict that and until you tried it you would never know.
2021-04-30 07:19 Kristian G. Andersen open

"until you tried it" - oh, but Andrew....
2021-04-30 07:56 Robert F. Garry open

or serially passaged it on ferrets.

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