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Slack / Private Message Drop, p.611 [SLACK_000825] · slack_pm:msg:06395

Page text: p.611 · original PDF

Date: 2021-03-21 14:41
Type: chat message · slack
recipient: Kristian G. Andersen, Robert F. Garry, Andrew Rambaut
speaker: Edward C. Holmes

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They only have 3 kb at the moment. Not quite sure which bit. I'll investigate.

In context

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2021-03-21 14:25 Edward C. Holmes open

Dominic told me that might be a week or two yet and that they had some WHO meetings lined up this week. Colleague just found an alpha coronavirus in a pangolin so clearly these animals are highly susceptible. [shared file(s): pangolin -CoV.png]
2021-03-21 14:36 Robert F. Garry open

Does it have a FCS?
2021-03-21 14:41 Edward C. Holmes

They only have 3 kb at the moment. Not quite sure which bit. I'll investigate.
2021-03-21 14:54 Robert F. Garry open

Raises a question as to whether pangolins are true reservoirs of multiple CoV lineages (possible) or just occasionally getting infected via spillovers - presumably from bats. Same question can be raised regarding SC1 visavis civets and the occasional raccoon dog - are these species true SC1 reservoirs or occasional spillovers? Related question - have humans gone from being spillover hosts to now being Ebola virus reservoirs? I think you could argue either way.
2021-03-21 15:02 Edward C. Holmes open

I suspect there are reservoirs. We are now seeing multiple lineages over multiple years - with Tommy we have seropositives dating back to Malaysia a few years ago. Hopefully will get sequences very soon. The key point is thatit won't just be bats and pangolins....
2021-03-21 15:14 Robert F. Garry open

I agree, and glad that Tommy is working hard on this question - it's important. The argument that civets are a true reservoirs of SC1 hinges on the fact that they were involved in both SC1 outbreaks a year apart. Your key point is -well very key! SC1 and 2 both pan-tropic - maybe the pango CoVs are as well.
2021-03-21 15:33 Edward C. Holmes open

China Covid researchers 'in first cluster' Virologist Shi Zheng-li, left, works with her colleague in the P4 lab of Wuhan Institute of Virology in central China's Hubei province in 2017. Picture: Getty Images· SHARRI MARKSONINVESTIGATIONS EDITOR• 6:06AM MARCH 22, 2021• 180 _COMMENTS_

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