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Slack / Private Message Drop, p.575 [SLACK_000789] · slack_pm:msg:06007

Page text: p.575 · original PDF

Date
2021-03-08 13:31
Type
chat message · slack
recipient
Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker
Kristian G. Andersen

Recipients on this medium are inferred from channel membership, not per-message addressing.

Maybe he should try selling poetry on Amazon - happy to provide him with material.

In context

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  1. 2021-03-08 13:18 Robert F. Garry open
    Billy aka Kevin has written a poem about @Kristian Andersen. He and Nicholson Baker should write something together. [shared file(s): image.png]
  2. 2021-03-08 13:19 Kristian G. Andersen open
    Andrew's tweet is spot on for that exact scenario [shared file(s): Screen Shot 2021-03-08 at 1.18.39 PM.png]
  3. 2021-03-08 13:19 Kristian G. Andersen open
    I like that poem - clever. I should frame it. Thanks Billy.
  4. 2021-03-08 13:27 Edward C. Holmes open
    Such great work from Billy. I'm just surprised he can't get financed.
  5. 2021-03-08 13:31 Kristian G. Andersen
    Maybe he should try selling poetry on Amazon - happy to provide him with material.
  6. 2021-03-08 13:51 Edward C. Holmes open
    Given how cock obsessed Billy is it's not hard to imagine how microscopic his own member must be. I also suspectit requires its own gain of function.
  7. 2021-03-08 14:16 Andrew Rambaut open
    I was going to ask - how hard is it to collect samples with cultureable viruses? From what I am hearing it is difficult toculture SARS-CoV-2 from many samples so I would imagine sampling bats (say) you would be just hoping for RNA rather than infectious virus.
  8. 2021-03-08 14:45 Robert F. Garry open
    Yes - hard to culture from natural samples. First issue is you are getting animals that are likely at different stages ininfections - early, late, persistent, recovering - who knows? We don't know how long viremia lasts in Mastomys with Lassa virus. Seems much lower than in humans. Rabies - long term infections, bats carry for a loooong time eventually some [all?] get sick. For SC2 from humans unless the Ct values are really low say low 20s it's very difficult. Not to say that there is not infectious virus there and that under the right circumstance (inhaling it directly into the nasal passages or lungs even a fairly low may be all it takes. I'm just guessing but unlikely bats would produce their Covs at high levels even if you caught then just right . The intermediate hosts/reservoirs, might grow virus to higher levels (like say civets for SC1), but probably varies a lot from animal to animal like humans . Sicksnotty nose pangolins might have higher loads for their viruses, too. Same apparently true of camels for MERS-CoV. All these considerations are why no-one's cultured ebola virus from a bat yet.
  9. 2021-03-08 14:54 Andrew Rambaut open
    And if you just out sampling to look for diversity you are probably going to store the samples to preserve RNA rather than hope to culture anything.

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