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Slack / Private Message Drop, p.562 [SLACK_000776] · slack_pm:msg:05865

Date: 2021-03-02 18:04
Type: chat message · slack
mentioned: Robert F. Garry
recipient: Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker: Kristian G. Andersen

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Back to science - we just picked up two _very_ interesting "CA" lineage viruses carrying the d144 deletion and a few other mutations, including N501Y and (more intriguingly) L455F - two out of six of the contact residues hit in a single lineage. L455F is rare - mostly seen in a few genomes from Australia. Eddie, do you have any idea if that mutation was looked into? @Robert Garry your eyes on L455F? Remember, the "CA" lineage has the L452R mutation too, so I wonder if those two together might do something funky. [shared file(s): Screen Shot 2021-03-02 at 6.01.56 PM.png, Protein alignment.geneious]

In context

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2021-03-02 17:55 Edward C. Holmes open

I don't know her at all, but clearly the fame has gone to her head. She did nothing to change that text. She's learnt all this from Trevor.
2021-03-02 17:57 Edward C. Holmes open

Richard Neher should have done some mentoring as well.
2021-03-02 17:59 Kristian G. Andersen open

Hah - you'd imagine him beating the Trevor out of her and replace it with physics smugness :wink:
2021-03-02 18:01 Edward C. Holmes open

Oh, don't get me started...
2021-03-02 18:04 Kristian G. Andersen

Back to science - we just picked up two _very_ interesting "CA" lineage viruses carrying the d144 deletion and a few other mutations, including N501Y and (more intriguingly) L455F - two out of six of the contact residues hit in a single lineage. L455F is rare - mostly seen in a few genomes from Australia. Eddie, do you have any idea if that mutation was looked into? @Robert Garry your eyes on L455F? Remember, the "CA" lineage has the L452R mutation too, so I wonder if those two together might do something funky. [shared file(s): Screen Shot 2021-03-02 at 6.01.56 PM.png, Protein alignment.geneious]
2021-03-02 18:05 Kristian G. Andersen open

The screenshot - two bottom sequences = new genomes. Above that, "Type" B.1.429 and above that, Wuhan Hu-1.
2021-03-02 18:13 Edward C. Holmes open

Can you tell me what the Australian sequences are? I'll look into it. No way that L455F will have been studied here.
2021-03-02 18:33 Kristian G. Andersen open

I can't... We're unfortunately not allowed to pull GISAID IDs... I can see UK has a few of the double mutants too. https://outbreak.info/situation-reports?pango&muts=S%3AN501Y&muts=S%3AL455F
2021-03-02 18:45 Edward C. Holmes open

Ok, I'll ask about it.

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