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Slack / Private Message Drop, p.549 [SLACK_000763] · slack_pm:msg:05720

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@Andrew Rambaut - I assume this isn't actually a pango issue, right? [shared file(s): Screen Shot 2021-02-25 at 08.51.50.png]

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A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-02-25 07:55 Kristian G. Andersen open

Interesting... Hasn't it previously been hypothesized that the FCS itself is involved in metal chelation, potentiallyexpanded the receptor usage of the virus? That site is pretty interesting- we also see R and L in that position at times:https://nextstrain.org/ncov/global?c=gt-S_152
2021-02-25 07:57 Kristian G. Andersen open

I'm talking to Charles later this morning btw - I think he got a little spooked and is realizing that maybe his data isshit... I think the potential transmission advantage of the variant is interesting, so worth looking at that further - but not the way Charles did. Won't matter in a few weeks though - B.1.1.7 is going in for the knockout.
2021-02-25 08:04 Robert F. Garry open

@Kristian Andersen Heparin sulfate binding I think.
2021-02-25 08:37 Kristian G. Andersen open

Charles actually looked at binding of W152C in his 'paper'. Decreased binding - by quite a bit (manu above). [shared file(s): Screen Shot 2021-02-25 at 08.36.44.png]
2021-02-25 08:52 Kristian G. Andersen

@Andrew Rambaut - I assume this isn't actually a pango issue, right? [shared file(s): Screen Shot 2021-02-25 at 08.51.50.png]
2021-02-25 09:10 Andrew Rambaut open

This was happening occasionally - a false positive P.1. probably due to convergence. We have fixed this now in the latest pangolin so P.1s will only be called based on having 5 or more of the defining mutations.