COVID-19 Records

Chat message

Slack / Private Message Drop, p.549 [SLACK_000763] · slack_pm:msg:05719

Page text: p.549 · original PDF

Date
2021-02-25 08:37
Type
chat message · slack
recipient
Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker
Kristian G. Andersen

Recipients on this medium are inferred from channel membership, not per-message addressing.

Charles actually looked at binding of W152C in his 'paper'. Decreased binding - by quite a bit (manu above). [shared file(s): Screen Shot 2021-02-25 at 08.36.44.png]

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

  1. 2021-02-25 07:52 Robert F. Garry open
    Someone with a cyroEM really needs to take a look.
  2. 2021-02-25 07:55 Kristian G. Andersen open
    Interesting... Hasn't it previously been hypothesized that the FCS itself is involved in metal chelation, potentiallyexpanded the receptor usage of the virus? That site is pretty interesting- we also see R and L in that position at times:https://nextstrain.org/ncov/global?c=gt-S_152
  3. 2021-02-25 07:57 Kristian G. Andersen open
    I'm talking to Charles later this morning btw - I think he got a little spooked and is realizing that maybe his data isshit... I think the potential transmission advantage of the variant is interesting, so worth looking at that further - but not the way Charles did. Won't matter in a few weeks though - B.1.1.7 is going in for the knockout.
  4. 2021-02-25 08:04 Robert F. Garry open
    @Kristian Andersen Heparin sulfate binding I think.
  5. 2021-02-25 08:37 Kristian G. Andersen
    Charles actually looked at binding of W152C in his 'paper'. Decreased binding - by quite a bit (manu above). [shared file(s): Screen Shot 2021-02-25 at 08.36.44.png]
  6. 2021-02-25 08:52 Kristian G. Andersen open
    @Andrew Rambaut - I assume this isn't actually a pango issue, right? [shared file(s): Screen Shot 2021-02-25 at 08.51.50.png]
  7. 2021-02-25 09:10 Andrew Rambaut open
    This was happening occasionally - a false positive P.1. probably due to convergence. We have fixed this now in the latest pangolin so P.1s will only be called based on having 5 or more of the defining mutations.

Full conversation →