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1. 2021-02-21 15:08 Edward C. Holmes open
   Did you see this: https://www.biorxiv.org/content/10.1101/2021.02.13.431090v1.full.pdf+html
2. 2021-02-21 15:09 Edward C. Holmes open
   I've not read it carefully yet, but interesting to see the adaptive changes in ORF1ab as well. They are dead right thatdN/dS is pretty rubbish when you have fixed mutations.
3. 2021-02-21 15:12 Kristian G. Andersen open
   Yeah, just saw it too - pretty interesting. And yes, "A" is totally unique to SC2 there
4. 2021-02-21 15:13 Edward C. Holmes open
   I'm in...sorry, just catching up this thread now.
5. 2021-02-21 15:14 Kristian G. Andersen
   it's nicely spotted, since it's the only mutation unique to SC2 in the RBD - we should have picked this up earlier. Iwonder if H519 does something interesting too.
6. 2021-02-21 15:16 Kristian G. Andersen open
   519 is "H" in SC2, but N in almost all other sequences - the only other deviation is K in the P378 pangolin, although that is a pretty bad sequence, so might not be real.
7. 2021-02-21 15:16 Edward C. Holmes open
   No one thinks about fixed changes: nicely blows-up the idea that SARS-CoV-2 was perfectly adapted to humans at the outset.
8. 2021-02-21 15:18 Kristian G. Andersen open
   Well, actually, this supports being perfectly adapted to humans :wink:. A in that position was fixed from the get go.
9. 2021-02-21 15:20 Kristian G. Andersen open
   (and yeah - dN/dS is shit. Just no point).

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