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Slack / Private Message Drop, p.536 [SLACK_000750] · slack_pm:msg:05579

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Yeah, just saw it too - pretty interesting. And yes, "A" is totally unique to SC2 there

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-02-21 15:08 Edward C. Holmes open

Did you see this: https://www.biorxiv.org/content/10.1101/2021.02.13.431090v1.full.pdf+html
2021-02-21 15:09 Edward C. Holmes open

I've not read it carefully yet, but interesting to see the adaptive changes in ORF1ab as well. They are dead right thatdN/dS is pretty rubbish when you have fixed mutations.
2021-02-21 15:12 Kristian G. Andersen

Yeah, just saw it too - pretty interesting. And yes, "A" is totally unique to SC2 there
2021-02-21 15:13 Edward C. Holmes open

I'm in...sorry, just catching up this thread now.
2021-02-21 15:14 Kristian G. Andersen open

it's nicely spotted, since it's the only mutation unique to SC2 in the RBD - we should have picked this up earlier. Iwonder if H519 does something interesting too.
2021-02-21 15:16 Kristian G. Andersen open

519 is "H" in SC2, but N in almost all other sequences - the only other deviation is K in the P378 pangolin, although that is a pretty bad sequence, so might not be real.
2021-02-21 15:16 Edward C. Holmes open

No one thinks about fixed changes: nicely blows-up the idea that SARS-CoV-2 was perfectly adapted to humans at the outset.