Chat message

Slack / Private Message Drop, p.534 [SLACK_000748] · slack_pm:msg:05563

Date: 2021-02-20 17:24
Type: chat message · slack
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry

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No problem at all - please keep the questions coming. I think the A701V could just be random. A to V a pretty conservative change, but A82V in Ebola virus was a pretty big deal. It's in the region between S1/S2 and S2' so itgets "cut out" during entry - some thoughts that the cutout peptide could have some "activity." Maybe, but it could just be a "spacer," Not close enough to the FCS to have an effect.

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2021-02-20 16:10 Edward C. Holmes open

Bob - can I have one more look over it today? Then post tomorrow?
2021-02-20 16:13 Edward C. Holmes open

I think the WIV is totally off the agenda for the WHO. My contacts say that the Chinese have been not looking into either. Let's face it, identifying a lab weak from WIV is a Yale lock with a credit card for the security services and yet they have fuck all.
2021-02-20 16:52 Andrew Rambaut open

Sorry to keep doing this to you Bob but have you any thoughts on A701V ? Close enough to FCS to have an effect?
2021-02-20 16:52 Andrew Rambaut open

Or just a nothing.
2021-02-20 17:24 Robert F. Garry

No problem at all - please keep the questions coming. I think the A701V could just be random. A to V a pretty conservative change, but A82V in Ebola virus was a pretty big deal. It's in the region between S1/S2 and S2' so itgets "cut out" during entry - some thoughts that the cutout peptide could have some "activity." Maybe, but it could just be a "spacer," Not close enough to the FCS to have an effect.

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