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Slack / Private Message Drop, p.528 [SLACK_000742] · slack_pm:msg:05502

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I think that all of the natural human-to-animals have been DouG/PhiL, but the fact that a PreDoug virus converted toPhiL in 10/10 monkeys is crazy...

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2021-02-19 14:45 Andrew Rambaut open

I heard from a confidential source that in macaque infections P323L (Phil) came up in 10/10 monkeys.
2021-02-19 14:46 Andrew Rambaut open

And yes Phil is strongly linked with Doug but came up first (in January).
2021-02-19 14:47 Andrew Rambaut open

I think it is probably the first major human adaptation
2021-02-19 14:48 Robert F. Garry open

Remarkable!
2021-02-19 14:50 Robert F. Garry

I think that all of the natural human-to-animals have been DouG/PhiL, but the fact that a PreDoug virus converted toPhiL in 10/10 monkeys is crazy...
2021-02-19 14:50 Kristian G. Andersen open

So why're we talking about "Doug took over the world"? I'd be _much_ more inclined to think Phil did and brought his friend Doug with him
2021-02-19 14:56 Robert F. Garry open

Just an impression but many [not all] of the places the nonPhiL viruses are lingering seem to be relatively low incidence countries.
2021-02-19 15:11 Robert F. Garry open

RaTG13 and SC1 have the proline at that site.
2021-02-19 15:12 Kristian G. Andersen open

Proves it came from the lab.