Chat message

Slack / Private Message Drop, p.512 [SLACK_000726] · slack_pm:msg:05345

Date: 2021-02-13 06:18
Type: chat message · slack
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry

Recipients on this medium are inferred from channel membership, not per-message addressing.

Just to add that viruses obviously do a lot of things to enhance replication besides just better adsorption, binding and fusion, including inhibiting interferonhttps://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1008737 . This is where nsp6 might come intoohttps://www.cell.com/cell-reports/pdfExtended/S2211-1247(20)31223-7 nsp6 also inhibitsautophagyhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203519/ which could enhance replication by preventingdegradation of its sometimes weird proteins. Why that particular 9 nucleotide deletion in nsp6 keeps popping is not clear - but it's an important clue - it fits the pattern of being in an external loop.

Links shared

journal https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1008737
journal https://www.cell.com/cell-reports/pdfExtended/S2211-1247(20)31223-7
gov https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203519/

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-02-13 06:18 Robert F. Garry

Just to add that viruses obviously do a lot of things to enhance replication besides just better adsorption, binding and fusion, including inhibiting interferonhttps://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1008737 . This is where nsp6 might come intoohttps://www.cell.com/cell-reports/pdfExtended/S2211-1247(20)31223-7 nsp6 also inhibitsautophagyhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203519/ which could enhance replication by preventingdegradation of its sometimes weird proteins. Why that particular 9 nucleotide deletion in nsp6 keeps popping is not clear - but it's an important clue - it fits the pattern of being in an external loop.
2021-02-13 06:56 Robert F. Garry open

@Eddie Holmes https://www.reuters.com/article/us-health-coronavirus-who-china/china-refused-to-pro[...]-raw-data-on-early-covid-cases-team-member-says-idUSKBN2AD090 One thing the investigation solidified is that the Grand Wizard is a tool - first "snapping" at Biden admin (who just said we want to look at the data) and now apparentlydissing DD and others on the "team." Just spits out the first thing that pops into his mind...
2021-02-13 07:02 Robert F. Garry open

@Eddie Holmes As for DRASTIC, it seem their main spokes-monkey (aka Kevin) has gone private. The WHO report must have them rattled. [shared file(s): image.png]
2021-02-13 07:45 Robert F. Garry open

@Andrew Rambaut Very good thought! doesn't affect the O-linked prediction however.

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