Slack / Private Message Drop — page 512

[2021-02-13 06:18:32] [Robert Garry] Just to add that viruses obviously do a lot of things to enhance replication besides just better adsorption, binding and fusion, including inhibiting interferon https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1008737 . This is where nsp6 might come in toohttps://www.cell.com/cell-reports/pdfExtended/S2211-1247(20)31223-7 nsp6 also inhibits autophagyhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203519/ which could enhance replication by preventing degradation of its sometimes weird proteins. Why that particular 9 nucleotide deletion in nsp6 keeps popping is not clear - but it's an important clue - it fits the pattern of being in an external loop. [2021-02-13 06:56:31] [Robert Garry] [thread - ID: 2021-02-10 19:40:57] @Eddie Holmes https://www.reuters.com/article/us-health-coronavirus-who-china/china-refused-to-pro[...]-raw-data -on-early-covid-cases-team-member-says-idUSKBN2AD090 One thing the investigation solidified is that the Grand Wizard is a tool - first "snapping" at Biden admin (who just said we want to look at the data) and now apparently dissing DD and others on the "team." Just spits out the first thing that pops into his mind... [2021-02-13 07:02:03] [Robert Garry] [thread - ID: 2021-02-10 19:40:57] @Eddie Holmes As for DRASTIC, it seem their main spokes-monkey (aka Kevin) has gone private. The WHO report must have them rattled. [shared file(s): image.png] [2021-02-13 07:45:48] [Robert Garry] [thread - ID: 2021-02-12 08:10:54] @Andrew Rambaut Very good thought! doesn't affect the O-linked prediction however. [2021-02-13 12:09:28] [Robert Garry] https://www.reuters.com/article/us-health-coronavirus-usa/white-house-cites-deep-con[...]o-covid-19-report-demand s-early-data-from-china-idUSKBN2AD0FX [2021-02-13 14:55:43] [Eddie Holmes] The phoney war is in full swing. I've chatting to my mate from CNN this morning. He's been talking to the WHO team and they seem to have evidence of a lot of early cases in Wuhan. Apparently, there are also 1000s of blood bank sample that have not been tested. He reckons that the WHO won't be allowed back. [2021-02-13 17:53:24] [Robert Garry] DD is doing as good as he can (impressed actually). On the other hand Daszak is just a disaster. Yes the early case thing (not to mention the frozen food concession) is not playing well. Will have to get really lucky with blood as there is not much SC2 there. Some non infectious, but it's going to be low, high Ct at best.. That awful CDC paper [and other] notwithstanding there is a lot of CROSS-REACTIVITY with seasonal CoVs {good paper in this week's Cell] so serology is going to be dicey at best. Yes - what you need to find - and you could get lucky - is a bunch of sera that binds multiple SC2 proteins and is neutralizing. Science has to lead us out of the Phoney War (TM) (well put!). I think the cambo, thai and bat post is really need next week. Eddie you did a masterful job sorting out the weak points! [2021-02-13 17:58:13] [Robert Garry] Real COVID-19 is not too hard to spot serologically - but with caveats - high correlation btwn rxty to Nucleoprotein, RBD and S2 PLUS neutralization. Caveat: you will get something like this in the very rare person with al lot of seasonal CoV infections.