Chat message

Slack / Private Message Drop, p.482 [SLACK_000696] · slack_pm:msg:05017

Recipients on this medium are inferred from channel membership, not per-message addressing.

Spike mutations: D614G, E484K, G769V, W152L

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-02-05 00:06 Andrew Rambaut open

@Eddie Holmes B.1.1.4 + E484K tree: [shared file(s): image.png]
2021-02-05 00:07 Andrew Rambaut open

So a recent cluster (presumably one at the top is an independent instance).
2021-02-05 00:09 Edward C. Holmes open

Thanks! So, a recent cluster of B.1.1.4 that have independently acquired EriK? Perhaps from the US?
2021-02-05 00:13 Edward C. Holmes open

Sorry, now seen your email! Thanks!!
2021-02-05 00:17 Andrew Rambaut

Spike mutations: D614G, E484K, G769V, W152L
2021-02-05 00:18 Andrew Rambaut open

We are currently looking at whether 484K is starting to appear more frequently (in multiple backgrounds) than it did before or whether we just have more cases and more sequencing.
2021-02-05 00:20 Edward C. Holmes open

Yes, very interesting question. That we are seeing it in Australia is perhaps tell-tale.
2021-02-05 00:20 Andrew Rambaut open

For your case I would say it is irrelevant with respect to action that it is a recent cluster - just that it has 484K. I.e., itis not a 'cluster of concern' but it has a mutation of concern.
2021-02-05 00:21 Andrew Rambaut open

If you look at the number of States that cluster spans - it does suggest widespread transmission in the US.