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Slack / Private Message Drop, p.459 [SLACK_000673] · slack_pm:msg:04769

Page text: p.459 · original PDF

Date: 2021-01-27 07:46
Type: chat message · slack
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry

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Here's the alignment file. [shared file(s): clustalo-E20210127-153037-0863-50955906-p2m.clustal_num]

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-01-27 07:02 Andrew Rambaut open

@Andrew Rambaut "Trimmed, Corrected & Pasteurised" - good gag.
2021-01-27 07:03 Andrew Rambaut open

@Andrew Rambaut I like the 'translation' of the Cambodian too.
2021-01-27 07:09 Robert F. Garry open

@Andrew Rambaut Actually I take it back. Daoyu aka Flavikins reborn after the twitter ban did say fake and fraudulent. [shared file(s): image.png]
2021-01-27 07:44 Robert F. Garry open

https://www.ncbi.nlm.nih.gov/nuccore/LC556375.1 THis I think is the Japan bat cov that was in the Nature newsarticle about cambobat cov. It's interesting like SC1 in the S1/2 junction but a 3 amino acid gap instead of 4relative to SC2. [shared file(s): image.png]
2021-01-27 07:46 Robert F. Garry

Here's the alignment file. [shared file(s): clustalo-E20210127-153037-0863-50955906-p2m.clustal_num]
2021-01-27 07:48 Robert F. Garry open

and the fasta files [shared file(s): betacovs fasta whole spike.docx]
2021-01-27 07:51 Robert F. Garry open

The indel structures of the the new asian bats are very interesting.
2021-01-27 08:04 Robert F. Garry open

I have a feeling that the other new bat covs will also fit in nicely....
2021-01-27 08:12 Robert F. Garry open

Oh and @Kristian Andersen correcting one mistake - THe cysteines in the sarbecos are very conserved but not 100%. RmYN02, (and noe the Thaibat and japan bat "deletes" or is missing a pair - Japan Bat essentially just excises the cysteine loop - of course it could will be the other way around with SC1 etc adding the new cysteine loop kinda like your "fake reinfection patient" just in the CTD instead of the NTD.

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